Masaki Hayasaka : rechercher sur Z-Library

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1

[IEEE 2017 5th International Workshop on Low Temperature Bonding for 3D Integration (LTB-3D) - Tokyo, Japan (2017.5.16-2017.5.18)] 2017 5th International Workshop on Low Temperature Bonding for 3D Integration (LTB-3D) - Bonding temperature dependence of GalnAsP/InP wafer grown on directly bonded InP/Si substrate

Aikawa, Masaki, Nishiyama, Tetsuo, Kamada, Yuya Onuki Naoki, Han, Xu, Periyanayagam, Gandhi Kallarasan, Uchida, Kazuki, Sugiyama, Hirokazu, Hayasaka, Natsuki, Shimomura, Kazuhiko

Année:

2017

Fichier:

PDF, 307 KB

2017

2

[IEEE 2017 5th International Workshop on Low Temperature Bonding for 3D Integration (LTB-3D) - Tokyo, Japan (2017.5.16-2017.5.18)] 2017 5th International Workshop on Low Temperature Bonding for 3D Integration (LTB-3D) - Lasing characteristics of MOVPE grown 1.5μΜ GalnAsP LD using directly bonded InP/Si substrate

Hayasaka, Natsuki, Nishiyama, Tetsuo, Onuki, Yuya, Kamada, Naoki, Han, Xu, Kallarasan, Periyanayagam Gandhi, Uchida, Kazuki, Sugiyama, Hirokazu, Aikawa, Masaki, Shimomura, Kazuhiko

Année:

2017

Fichier:

PDF, 301 KB

2017

3

[IEEE 2019 24th OptoElectronics and Communications Conference (OECC) and 2019 International Conference on Photonics in Switching and Computing (PSC) - Fukuoka, Japan (2019.7.7-2019.7.11)] 2019 24th OptoElectronics and Communications Conference (OECC) and 2019 International Conference on Photonics in Switching and Computing (PSC) - Lasing characteristics of GalnAsP SCH-MQW Laser Diode on Directly-bonded InP/Si Substrate

Ishizaki, Takahiro, Uchida, Kazuki, Sugiyama, Hirokazu, Han, Xu, Hayasaka, Natsuki, Aikawa, Masaki, Matsuura, Masaki, Tsushima, Koki, Shirai, Takuto, Shimomura, Kazuhiko

Année:

2019

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2019

4

Amplitude of the s-Wave of Multifocal Electroretinograms Can Indicate Local Retinal Sensitivity in Glaucomatous Eyes

Ken-ichi Murai, Yutaka Tazawa, Masaki Kobayashi, Akira Hayasaka

Journal:

Japanese Journal of Ophthalmology

Année:

2004

Langue:

english

Fichier:

PDF, 208 KB

english, 2004

5

Nanoparticle recovery using a fume collector comprised of carbonized refuse-derived fuel

Tomohiro Akiyama, Nobuo Akae, Masaki Hayasaka, Nobuyuki Ishikawa

Journal:

Metallurgical and Materials Transactions B

Année:

2004

Langue:

english

Fichier:

PDF, 319 KB

english, 2004

6

Regulation of Early Gene Expression of Human Papillomavirus Type 16 by Inflammatory Cytokines

Satoru Kyo, Masaki Inoue, Naoto Hayasaka, Tadao Inoue, Masuo Yutsudo, Osamu Tanizawa, Akira Hakura

Journal:

Année:

1994

Fichier:

PDF, 720 KB

1994

7

Visualization of dynamic change in contraction-induced lipid composition in mouse skeletal muscle by matrix-assisted laser desorption/ionization imaging mass spectrometry

Goto-Inoue, Naoko, Manabe, Yasuko, Miyatake, Shouta, Ogino, Shinya, Morishita, Ai, Hayasaka, Takahiro, Masaki, Noritaka, Setou, Mitsutoshi, Fujii, Nobuharu L.

Journal:

Analytical and Bioanalytical Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 893 KB

english, 2012

8

Measurement of pure hydrogen and pure carbon dioxide adsorption equilibria for THF clathrate hydrate and tetra-n-butyl ammonium bromide semi-clathrate hydrate

Komatsu, Hiroyuki, Hayasaka, Atsushi, Ota, Masaki, Sato, Yoshiyuki, Watanabe, Masaru, Smith, Richard L.

Journal:

Fluid Phase Equilibria

Année:

2013

Langue:

english

Fichier:

PDF, 771 KB

english, 2013

9

Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4

Kurabe, Nobuya, Hayasaka, Takahiro, Ogawa, Mikako, Masaki, Noritaka, Ide, Yoshimi, Waki, Michihiko, Nakamura, Toshio, Kurachi, Kiyotaka, Kahyo, Tomoaki, Shinmura, Kazuya, Midorikawa, Yutaka, Sugiyama,

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 2.44 MB

english, 2013

10

Blockade of IL-6 signaling by MR16-1 inhibits reduction of docosahexaenoic acid-containing phosphatidylcholine levels in a mouse model of spinal cord injury

Arima, H., Hanada, M., Hayasaka, T., Masaki, N., Omura, T., Xu, D., Hasegawa, T., Togawa, D., Yamato, Y., Kobayashi, S., Yasuda, T., Matsuyama, Y., Setou, M.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 2.50 MB

english, 2014

11

Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor

He, Qian, Takizawa, Yoshinori, Hayasaka, Takahiro, Masaki, Noritaka, Kusama, Yukiko, Su, Jiping, Mineta, Hiroyuki, Setou, Mitsutoshi

Journal:

Analytical and Bioanalytical Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2014

12

Single-cell time-of-flight secondary ion mass spectrometry reveals that human breast cancer stem cells have significantly lower content of palmitoleic acid compared to their counterpart non-stem cancer cells

Waki, Michihiko, Ide, Yoshimi, Ishizaki, Itsuko, Nagata, Yasuyuki, Masaki, Noritaka, Sugiyama, Eiji, Kurabe, Nobuya, Nicolaescu, Dan, Yamazaki, Fumiyoshi, Hayasaka, Takahiro, Ikegami, Koji, Kondo, Tak

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2014

13

Single cell lipidomics of SKBR-3 breast cancer cells by using time-of-flight secondary-ion mass spectrometry

Ide, Yoshimi, Waki, Michihiko, Ishizaki, Itsuko, Nagata, Yasuyuki, Yamazaki, Fumiyoshi, Hayasaka, Takahiro, Masaki, Noritaka, Ikegami, Koji, Kondo, Takeshi, Shibata, Kiyoshi, Ogura, Hiroyuki, Sanada,

Journal:

Surface and Interface Analysis

Année:

2014

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2014

14

Erratum to: Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor

He, Qian, Takizawa, Yoshinori, Hayasaka, Takahiro, Masaki, Noritaka, Kusama, Yukiko, Su, Jiping, Mineta, Hiroyuki, Setou, Mitsutoshi

Journal:

Analytical and Bioanalytical Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 228 KB

english, 2014

15

Direct profiling of the phospholipid composition of adultCaenorhabditis elegansusing whole-body imaging mass spectrometry

Hameed, Saira, Ikegami, Koji, Sugiyama, Eiji, Matsushita, Shoko, Kimura, Yoshishige, Hayasaka, Takahiro, Sugiura, Yuki, Masaki, Noritaka, Waki, Michihiko, Ohta, Isao, Hossen, Md Amir, Setou, Mitsutosh

Journal:

Analytical and Bioanalytical Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 6.62 MB

english, 2015

16

Reductions of docosahexaenoic acid-containing phosphatidylcholine levels in the anterior horn of an ALS mouse model

Arima, H., Omura, T., Hayasaka, T., Masaki, N., Hanada, M., Xu, D., Banno, T., Kobayashi, K., Takeuchi, H., Kadomatsu, K., Matsuyama, Y., Setou, M.

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2015

17

Imaging mass spectrometry detects dynamic changes of phosphatidylcholine in rat hippocampal CA1 after transient global ischemia

Miyawaki, S., Imai, H., Hayasaka, T., Masaki, N., Ono, H., Ochi, T., Ito, A., Nakatomi, H., Setou, M., Saito, N.

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 6.59 MB

english, 2016

18

Volatile p-Nitroaniline as Matrix for High Spatial Resolution Imaging of Phospholipids in Both Ion Modes by AP-MALDI-IMS

Matsushita, Shoko, Sugiyama, Eiji, Hayasaka, Takahiro, Masaki, Noritaka, Setou, Mitsutoshi

Journal:

Microscopy and Microanalysis

Année:

2014

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2014

19

Application of 2,5-dihydroxyacetophenone with sublimation provides efficient ionization of lipid species by atmospheric pressure matrix-assisted laser desorption/ionization imaging mass spectrometry

Hayasaka, Takahiro, Goto-Inoue, Naoko, Masaki, Noritaka, Ikegami, Koji, Setou, Mitsutoshi

Journal:

Surface and Interface Analysis

Année:

2014

Langue:

english

Fichier:

PDF, 1.22 MB

english, 2014

20

Imaging Mass Spectrometry Reveals a Unique Distribution of Triglycerides in the Abdominal Aortic Aneurysmal Wall

Tanaka, Hiroki, Zaima, Nobuhiro, Sasaki, Takeshi, Yamamoto, Naoto, Inuzuka, Kazunori, Sano, Masaki, Saito, Takaaki, Hayasaka, Takahiro, Goto-Inoue, Naoko, Sato, Kohji, Kugo, Hirona, Moriyama, Tatsuya,

Journal:

Journal of Vascular Research

Année:

2015

Langue:

english

Fichier:

PDF, 1.82 MB

english, 2015

21

Accumulation of arachidonic acid-containing phosphatidylinositol at the outer edge of colorectal cancer

Hiraide, Takanori, Ikegami, Koji, Sakaguchi, Takanori, Morita, Yoshifumi, Hayasaka, Takahiro, Masaki, Noritaka, Waki, Michihiko, Sugiyama, Eiji, Shinriki, Satoru, Takeda, Makoto, Shibasaki, Yasushi, M

Journal:

Scientific Reports

Année:

2016

Langue:

english

Fichier:

PDF, 1.88 MB

english, 2016

22

The Optimal Duration of PTH(1–34) Infusion Is One Hour per Day to Increase Bone Mass in Rats

Shimizu, Masaru, Noda, Hiroshi, Joyashiki, Eri, Nakagawa, Chie, Asanuma, Kentaro, Hayasaka, Akira, Kato, Motohiro, Nanami, Masahiko, Inada, Masaki, Miyaura, Chisato, Tamura, Tatsuya

Année:

2016

Langue:

english

Fichier:

PDF, 577 KB

english, 2016

23

Nd-isotopic composition of Phanerozoic sediments in the Inner Zone of Southwest Japan Arc: implications on provenance characteristics and contribution to formation of mature island arc system

KAGAMI, Hiroo, KAWANO, Yoshinobu, IKAWA, Toshiyuki, NISHI, Naoko, TOYOSHIMA, Tsuyoshi, HAMAMOTO, Takuji, HAYASAKA, Yasutaka, IKEDA, Yasuo, YUHARA, Masaki, TAINOSHO, Yoshiaki

Journal:

Proceedings of the Japan Academy Series B Physical and Biological Sciences

Année:

2004

Langue:

english

Fichier:

PDF, 841 KB

english, 2004

24

Selective improvement of peptides imaging on tissue by supercritical fluid wash of lipids for matrix-assisted laser desorption/ionization mass spectrometry

Matsushita, Shoko, Masaki, Noritaka, Sato, Kohei, Hayasaka, Takahiro, Sugiyama, Eiji, Hui, Shu-Ping, Chiba, Hitoshi, Mase, Nobuyuki, Setou, Mitsutoshi

Journal:

Analytical and Bioanalytical Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.76 MB

english, 2017

25

Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia

Matsumoto, Junya, Nakanishi, Hiroki, Kunii, Yasuto, Sugiura, Yuki, Yuki, Dai, Wada, Akira, Hino, Mizuki, Niwa, Shin-Ichi, Kondo, Takeshi, Waki, Michihiko, Hayasaka, Takahiro, Masaki, Noritaka, Akatsu,

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 1.25 MB

english, 2017

26

Different desmin peptides are distinctly deposited in cytoplasmic aggregations and cytoplasm of desmin-related cardiomyopathy patients

Shintani-Domoto, Yukako, Hayasaka, Takahiro, Maeda, Daichi, Masaki, Noritaka, Ito, Takashi K., Sakuma, Kei, Tanaka, Michio, Kabashima, Katsuya, Takei, Shiro, Setou, Mitsutoshi, Fukayama, Masashi

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Année:

2017

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2017

27

Three-Dimensional Image of Cleavage Bodies in Nuclei Is Configured Using Gas Cluster Ion Beam with Time-of-Flight Secondary Ion Mass Spectrometry

Masaki, Noritaka, Ishizaki, Itsuko, Hayasaka, Takahiro, Fisher, Gregory L., Sanada, Noriaki, Yokota, Hideo, Setou, Mitsutoshi

Journal:

Scientific Reports

Année:

2015

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2015

28

[IEEE 2017 Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR) - Singapore, Singapore (2017.7.31-2017.8.4)] 2017 Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR) - Low threshold current of GalnAsP laser grown on directly bonded InP/Si substrate

Sugiyama, Hirokazu, Nishiyama, Tetsuo, Kamada, Naoki, Onuki, Yuya, Han, Xu, Periyanayagam, Gandhi Kallarasan, Aikawa, Masaki, Hayasaka, Natsuki, Uchida, Kazuki, Shimomura, Kazuhiko

Année:

2017

Langue:

english

Fichier:

PDF, 472 KB

english, 2017

29

Bonding temperature dependence of GaInAsP/InP laser diode grown on hydrophilically directly bonded InP/Si substrate

Aikawa, Masaki, Onuki, Yuya, Hayasaka, Natsuki, Nishiyama, Tetsuo, Kamada, Naoki, Han, Xu, Periyanayagam, Gandhi Kallarasan, Uchida, Kazuki, Sugiyama, Hirokazu, Shimomura, Kazuhiko

Journal:

Japanese Journal of Applied Physics

Année:

2018

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2018

30

Herpes zoster ophthalmicus Complicated by Hyphema and Hemorrhagic Glaucoma

Hayasaka, Seiji, Watanabe, Masaki, Yamamoto, Yukari, Noda, Sachiko, Sekimoto, Mihoko, Setogawa, Tomoichi

Journal:

Ophthalmologica

Année:

1988

Langue:

english

Fichier:

PDF, 351 KB

english, 1988

31

Optic Nerve Hypoplasia Associated with Porencephalia in a Girl and Retinitis pigmentosa in Her Sister

Fukuyama, Jun-ichiro, Hayasaka, Seiji, Setogawa, Tomoichi, Watanabe, Masaki, Saito, Jun

Journal:

Ophthalmologica

Année:

1991

Langue:

english

Fichier:

PDF, 771 KB

english, 1991

32

[IEEE 2017 Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR) - Singapore, Singapore (2017.7.31-2017.8.4)] 2017 Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR) - Lasing characteristics of GalnAsP stripe laser integrated on InP/Si substrate

Uchida, Kazuki, Nishiyama, Tetsuo, Kamada, Naoki, Onuki, Yuya, Han, Xu, Periyanayagam, Gandhi Kallarasan, Sugiyama, Hirokazu, Aikawa, Masaki, Hayasaka, Natsuki, Shimomura, Kazuhiko

Année:

2017

Langue:

english

Fichier:

PDF, 492 KB

english, 2017

33

Mapping altered brain connectivity and its clinical associations in adult moyamoya disease: A resting-state functional MRI study

Kazumata, Ken, Tha, Khin Khin, Uchino, Haruto, Ito, Masaki, Nakayama, Naoki, Abumiya, Takeo, Hayasaka, Satoru

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 8.59 MB

english, 2017

34

Increased Expression of Phosphatidylcholine (16:0/18:1) and (16:0/18:2) in Thyroid Papillary Cancer

Ishikawa, Seiji, Tateya, Ichiro, Hayasaka, Takahiro, Masaki, Noritaka, Takizawa, Yoshinori, Ohno, Satoshi, Kojima, Tsuyoshi, Kitani, Yoshiharu, Kitamura, Morimasa, Hirano, Shigeru, Setou, Mitsutoshi,

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 2.65 MB

english, 2012

35

Adventitial Vasa Vasorum Arteriosclerosis in Abdominal Aortic Aneurysm

Tanaka, Hiroki, Zaima, Nobuhiro, Sasaki, Takeshi, Hayasaka, Takahiro, Goto-Inoue, Naoko, Onoue, Kenji, Ikegami, Koji, Morita, Yoshifumi, Yamamoto, Naoto, Mano, Yuuki, Sano, Masaki, Saito, Takaaki, Sat

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 4.47 MB

english, 2013

36

Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm

Tanaka, Hiroki, Zaima, Nobuhiro, Sasaki, Takeshi, Sano, Masaki, Yamamoto, Naoto, Saito, Takaaki, Inuzuka, Kazunori, Hayasaka, Takahiro, Goto-Inoue, Naoko, Sugiura, Yuki, Sato, Kohji, Kugo, Hirona, Mor

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 16.83 MB

english, 2015

37

The Distribution of Phosphatidylcholine Species in Superficial-Type Pharyngeal Carcinoma

Ishikawa, Seiji, Tateya, Ichiro, Hayasaka, Takahiro, Shinriki, Satoru, Masaki, Noritaka, Hirano, Shigeru, Kitamura, Morimasa, Muto, Manabu, Morita, Shuko, Setou, Mitsutoshi, Ito, Juichi

Journal:

BioMed Research International

Année:

2017

Langue:

english

Fichier:

PDF, 3.98 MB

english, 2017

38

MALDI Imaging Mass Spectrometry—A Mini Review of Methods and Recent Developments

Eriksson, Cecilia, Masaki, Noritaka, Yao, Ikuko, Hayasaka, Takahiro, Setou, Mitsutoshi

Journal:

Mass Spectrometry

Année:

2013

Fichier:

PDF, 6.63 MB

2013

39

[OSA CLEO: Applications and Technology - San Jose, California (2018..-..)] Conference on Lasers and Electro-Optics - 1.5 μm GaInAsP Stripe Laser Comparison Between InP Substrate and Directly Bonded InP/Si Substrate

Kallarasan, Periyanayagam Gandhi, Kamada, Naoki, Onuki, Yuya, Uchida, Kazuki, Sugiyama, Hirokazu, Han, Xu, Hayasaka, Natsuki, Aikawa, Masaki, Shimomura, Kazuhiko

Année:

2018

Langue:

english

Fichier:

PDF, 652 KB

english, 2018

40

MALDI Imaging Mass Spectrometry—A Mini Review of Methods and Recent Developments

Eriksson, Cecilia, Masaki, Noritaka, Yao, Ikuko, Hayasaka, Takahiro, Setou, Mitsutoshi

Journal:

Mass Spectrometry

Année:

2013

Langue:

english

Fichier:

PDF, 6.63 MB

english, 2013

41

Effects of perinatal blood pressure on maternal brain functional connectivity

Kurosaki, Hiromichi, Nakahata, Katsutoshi, Donishi, Tomohiro, Shiro, Michihisa, Ino, Kazuhiko, Terada, Masaki, Kawamata, Tomoyuki, Kaneoke, Yoshiki, Hayasaka, Satoru

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 7.36 MB

english, 2018

42

Structures and Catalytic Activities of Complexes between Heme and All Parallel-Stranded Monomeric G-Quadruplex DNAs

Yamamoto, Yasuhiko, Araki, Haruka, Shinomiya, Ryosuke, Hayasaka, Kosuke, Nakayama, Yusaku, Ochi, Kentaro, Shibata, Tomokazu, Momotake, Atsuya, Ohyama, Takako, Hagihara, Masaki, Hemmi, Hikaru

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2018

43

MOVPE grown GaInAsP/GaInAsP SCH-MQW laser diode on directly- bonded InP/Si substrate

Sugiyama, Hirokazu, Uchida, Kazuki, Han, Xu, Kallarasan Periyanayagam, Gandhi, Aikawa, Masaki, Hayasaka, Natsuki, Shimomura, Kazuhiko

Journal:

Journal of Crystal Growth

Année:

2018

Langue:

english

Fichier:

PDF, 2.59 MB

english, 2018

44

Vortex Veins in the Macula

Sekimoto, Mihoko, Hayasaka, Seiji, Watanabe, Masaki, Setogawa, Tomoichi

Journal:

Ophthalmologica

Année:

1988

Langue:

english

Fichier:

PDF, 341 KB

english, 1988

45

Atmospheric Pressure MALDI-IMS Using p-Nitroaniline as the Matrix at High Spatial Resolution in the Positive and Negative Ion Modes

MATSUSHITA, Shoko, SUGIYAMA, Eiji, HAYASAKA, Takahiro, MASAKI, Noritaka, SETOU, Mitsutoshi

Journal:

Journal of the Mass Spectrometry Society of Japan

Année:

2014

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2014

46

Identification of CCDC180 and LRRC4 as Potential Immunohistochemical Markers for Liposarcoma Based on Proteomic Analysis Using Formalin-Fixed, Paraffin-Embedded Tissue

Aoyama, Tomoyuki, Takasawa, Akira, Takasawa, Kumi, Ono, Yusuke, Emori, Makoto, Murata, Masaki, Hayasaka, Takahiro, Fujitani, Naoki, Osanai, Makoto, Yamashita, Toshihiko, Hasegawa, Tadashi, Sawada, Nor

Journal:

The American Journal of Pathology

Année:

2019

Langue:

english

Fichier:

PDF, 14.31 MB

english, 2019

47

[IEEE 2019 24th OptoElectronics and Communications Conference (OECC) and 2019 International Conference on Photonics in Switching and Computing (PSC) - Fukuoka, Japan (2019.7.7-2019.7.11)] 2019 24th OptoElectronics and Communications Conference (OECC) and 2019 International Conference on Photonics in Switching and Computing (PSC) - Lasing Characteristics of GalnAsP SCH MQW High-mesa Laser on Silicon Substrate

Tsushima, Koki, Uchida, Kazuki, Han, Xu, Sugiyama, Hirokazu, Aikawa, Masaki, Hayasaka, Natsuki, Matsuura, Masaki, Ishizaki, Takahiro, Shirai, Takuto, Shimomura, Kazuhiko

Année:

2019

Fichier:

PDF, 1.02 MB

2019